The purpose of this study is to identify circulating tumor cells in patients with solid tumors. Quantify and characterize these cells, collect patient information in regards to the patient's cancer. Develop a database and a sample repository where future analysis could be done.

The primary purpose of this correlative study is to create a prospective database documenting the quantity and characterization of circulating tumor cells (CTCs) in solid tumor patients as identified by a various laboratory techniques and analyses. The investigators are developing this resource to provide data to achieve the following objectives: 1) correlate CTCs with known prognostic factors, 2) correlate CTCs with burden of disease, 3) evaluate the ability of CTCs to be used in the surveillance of disease recurrence, and 4) evaluate CTCs ability to be used as a biomarker for treatment response.

Inclusion Criteria:

• Age ≥ 18 years of age
• Biopsy proven solid tumor malignancy
• Seen at UNC Chapel Hill Hospital and Health Care System
• Consents to abstraction of their medical records
• Signed an institutional review board (IRB)-approved informed consent document for this protocol

Exclusion Criteria:

• < 18 years of age
• Dementia, altered mental status, incarceration or any psychiatric condition that would prohibit the understanding or rendering of informed consent.

Patients with cancerous solid tumors