Human Mass Balance Study of HMS5552 in Healthy Subjects

An Open-Label, Single Center Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of a Single Oral Dose of 50 mg (90 uCi) [14C]-HMS5552 in Healthy Adult Male Subjects

This is an open-label, single center, 1-period study in healthy adult male subjects to assess absorption, metabolism, and excretion of HMS5552 after a single oral administration of 50 mg (90 μCi) of [14C]-HMS5552.

Inclusion Criteria:

• Healthy, adult, male 19-55 years of age
• Weight at least 50 kg, and BMI within the range of 18-30 kg/m2
• Written informed consent must be obtained before any assessment is performed

Exclusion Criteria:

• History or presence of clinically significant medical, surgical or psychiatric condition or disease in the opinion of the Investigator or designee which might significantly alter the absorption, distribution, metabolism and excretion of drugs.
• History or presence of alcoholism or drug abuse.
• Smoker.
• Abnormal bowel habits.