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Cytokine-induced killer (CIK) cells will be co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to Condylomata Acuminata patients using interferon, whose recurrence rate and total cost will be compared to Condylomata Acuminata patients only use interferon.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DC-CIK+interferon Group | Experimental | dendritic cell-activated cytokine-induced killer cells (DC-CIK) immunotherapy plus interferon intervention |
|
| Placebo+interferon Group | Placebo Comparator | saline as placebo plus interferon intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DC-CIK immunotherapy | Biological | Cytokine-induced killer (CIK) cells are co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to condylomata acuminata patients |
| Measure | Description | Time Frame |
|---|---|---|
| Condylomata Acuminata recurrence rate | Condylomata Acuminata recurrence rate in 6 months after treatment | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| skin tissue HPV gene | use PCR to testify skin tissue HPV gene | 6 months |
| side effect | evaluate and record side effect of each group | 6 months |
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Inclusion Criteria:All patients have typical clinical characters of condyloma, positive for HPV-DNA test; All patients have been treated for cryotherapy or laser plus interferon for over half a year without completely recovery. All patients or their family will sign informed consent and approved by Ethics Committee of Shenzhen Second People's Hospital -
Exclusion Criteria:pregnant, blood disease, contraindication for immune therapy, allergic to interferon
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shenzhen Second Hospital | Recruiting | Shenzhen | Guangdong | China |
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| ID | Term |
|---|---|
| D003218 | Condylomata Acuminata |
| ID | Term |
|---|---|
| D030361 | Papillomavirus Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D003141 | Communicable Diseases |
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| D007239 | Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D014860 | Warts |
| D017193 | Skin Diseases, Viral |
| D014412 | Tumor Virus Infections |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D012874 | Skin Diseases, Infectious |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |