The AQLQ is a 32-item asthma specific questionnaire designed to measure functional impairments that are most important to patients with asthma, with a recall time of two weeks and each question to be answered on a 7-point scale, where 1=totally limited/problems all the time and 7= not at all limited/no problems. It consists of 4 domains: symptoms, activity limitation, emotional funtion, and emotional stimuli. The overall score is calculated as the mean of 32 items. Higher AQLQ scores indicate better health-related quality of life.

Analysis population included FAS with evaluable AQLQ data at both timepoints. No imputation was used for missing questions or missing total AQLQ score for this analysis. The analysis was performed on observed data only.

FEV1 is the amount of air which can be forcibly exhaled from the lungs in the first second of a forced exhalation, measured through spirometry testing. Trough FEV1 is the mean of two FEV1 values measures taken 15 minutes (min) and 45 min prior to evening dose.

Analysis population included FAS with FEV1 data at the respective visit. Number analyzed signified number of participants who were evaluable for this outcome measure at specified timepoints.

The ACQ-7 measured asthma symptom control and consists of 7 items: 5 on symptom assessment, 1 on rescue medication use and 1 on airway calibre (FEV1 % predicted). All seven items are scored on a 7-point Likert scale, with 0 indicating total control and 6 indicating poor control. The questions are equally weighted and the total score is the mean of the seven items. Higher score indicates worst symptoms. The first 6 questions of the ACQ-7 were completed by the participant while the last question was completed by the study investigator using data from the Master Scope spirometer. A negative change from baseline indicates improvement in lung function.

Analysis population included FAS with ACQ-7 data at the respective visit. Number analyzed signified number of participants who were evaluable for this measure at specified timepoints. No imputation was used for missing questions or missing total ACQ-7 score for this analysis. The analysis was performed on observed data only

The AQLQ is a 32-item asthma specific questionnaire designed to measure functional impairments that are most important to patients with asthma, with a recall time of two weeks and each question to be answered on a 7-point scale, where 1=totally limited/problems all the time and 7= not at all limited/no problems. It consists of 4 domains: symptoms, activity limitation, emotional function and environmental stimuli. The overall score is calculated as the mean of 32 items. Higher AQLQ scores indicate better health-related quality of life.

Analysis population included FAS with evaluable AQLQ data at both timepoints. No imputation was used for missing questions or missing total AQLQ score for this analysis. The analysis was performed on observed data only

The ACQ-7 measured asthma symptom control and consists of 7 items: 5 on symptom assessment, 1 on rescue medication use and 1 on airway calibre (FEV1 % predicted). All seven items are scored on a 7-point Likert scale, with 0 indicating total control and 6 indicating poor control. The questions are equally weighted and the total score is the mean of the seven items. Higher score indicates worst symptoms. The first 6 questions of the ACQ-7 were completed by the participant while the last question was completed by the study investigator using data from the Master Scope spirometer. A negative change from baseline indicates improvement in lung function. Decrease of ACQ-7 score of at least 0.5 from baseline was considered clinically meaningful.

Analysis population included FAS with evaluable ACQ-7 data at both timepoints. Missing data imputation was used to perform this analysis. Subjects with missing values were imputed as non-responders (a non-responder was defined as <0.5 decrease in ACQ-7 score at week 24)

The AQLQ is a 32-item asthma specific questionnaire designed to measure functional impairments that are most important to patients with asthma, with a recall time of two weeks and each question to be answered on a 7-point scale, where 1=totally limited/problems all the time and 7= not at all limited/no problems. It consists of 4 domains: symptoms, activity limitation, emotional function and environmental stimuli. The overall score is calculated as the mean of 32 items. Higher AQLQ scores indicate better health-related quality of life. An improvement of 0.5 points in AQLQ score is considered to be the minimally clinically important difference in asthma.

Analysis population included FAS with evaluable AQLQ data at both timepoints. Missing data imputation was used to perform this analysis. Subjects with missing values were imputed as non-responders (a non-responder was defined as <0.5 increase in AQLQ score at week 24)

FVC is the total volume of air exhaled during a expiratory maneuvre. It was assessed by performing a spirometry assessment.

Analysis population included FAS with FVC data at the respective visit. Number analyzed signified number of participants who were evaluable for this measure at specified timepoints.

Forced expiratory flow during the mid (25 - 75%) portion of the FVC. It was assessed by performing spirometric assessment.

Analysis population included FAS with FEF25-75 data at the respective visit. Number analyzed signified number of participants who were evaluable for this measure at specified timepoints.