the aim of this study is to assess whether increased ferritin after intravenous iron therapy will lead to increased prevalence of major depression among treated patients.

Inclusion Criteria:

1. age was above 19 years,
2. patient on maintenance hemodialysis,
3. patient had iron deficiency anemia (ferritin > 100 ng/ml)

Exclusion Criteria:

1. patient has history of depression or already using antidepressant medication,
2. Lack of ferritin level increase ≥ 50% from baseline level before IV iron administration,
3. patient already on oral or intravenous iron supplement

Hemodialysis patients with iron deficiency anemia.