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Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality. The all-cause mortality rate at the international level is 10% at 30 days and 34% at one year. Mortality at 30 days is secondary in 66% of cases with DPG or multi-organ failure.
The treatment of choice for the more severe PDG remains ECMO-type circulatory mechanical assistance or ventricular assistance. According to several studies, this could reduce early mortality. Early placement and short-term (<30 days) of support appear to improve survival in the first year after transplantation.
The haemodynamic parameters revealing this DPG are not clearly described in the literature.
hypothesis of this research is that:
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| Measure | Description | Time Frame |
|---|---|---|
| Retrospective comparison of risk factors (incidence for ordinal and average variables for numerical variables) between patients suffering from severe primary dysfunction of the graft and those not suffering from severe primary dysfunction of the graft | 1 month after leaving the operating room |
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Inclusion Criteria:
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All patients who had an isolated heart transplant in the cardiac surgery department of HUS (HĂ´pitaux Univertsitaires de Strasbourg) between June 2008 and December 2015.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gharib AJOB, MD | Contact | 33 3 69 54 97 58 | gharib.ajob@chru-strasbourg.fr | |
| Alexandre DI MARCO, MD | Contact | 33 3 69 55 05 57 | alexandre.dimarco@chru-strasbourg.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service Réanimation chirurgicale cardio-vasculaire - NHC | Recruiting | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| D055031 | Primary Graft Dysfunction |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D015427 | Reperfusion Injury |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D011183 | Postoperative Complications |
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| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006331 | Heart Diseases |