Salivary Markers in Patients With Xerostomia | NCT03156569 | Trialant

Salivary Markers in Patients With Xerostomia | NCT03156569 | Trialant

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
saliva flow rate	Unstimulated salivary flow rate. Pathological < or 1.5 ml/ 15 minutes.	2 months
Xerostomia	Visual Analogue Scale (VAS) for xerostomia severity (0 cm: no xerostomía , 10cm : very severe xerostomia ).	2 months
Interleukins	Analytes in saliva IFN-(pg/ml), IL-10(pg/ml), IL-1b(pg/ml), IL-4 (pg/ml)and IL-6 (pg/ml)	2 months

Secondary Outcomes

Measure	Description	Time Frame
Oral Exam	Caries number, natural teeth number	4 months
Periodontal evaluation	periodontal( gingival index, bleeding index, clinical attachment level, probing depth,number dental implant .A periodontal probe will be inserted between the tooth and the gum in the gingival sulcus and a measurement of the pocket depth will be measured by a trained dentist in all subjects according to American Academy of Periodontology classification of periodontal diagnosis

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
24750447	Background	Ohyama K, Moriyama M, Hayashida JN, Tanaka A, Maehara T, Ieda S, Furukawa S, Ohta M, Imabayashi Y, Nakamura S. Saliva as a potential tool for diagnosis of dry mouth including Sjogren's syndrome. Oral Dis. 2015 Mar;21(2):224-31. doi: 10.1111/odi.12252. Epub 2014 May 15.
17451498	Result	van den Berg I, Pijpe J, Vissink A. Salivary gland parameters and clinical data related to the underlying disorder in patients with persisting xerostomia. Eur J Oral Sci. 2007 Apr;115(2):97-102. doi: 10.1111/j.1600-0722.2007.00432.x.