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This will be a randomized, cross-over design. Subjects will be randomized to one of six interventions on six separate study days, 1 week apart.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meal replacement A | Active Comparator |
| |
| Meal replacement B | Active Comparator |
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| Meal replacement C | Active Comparator |
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| Meal replacement D | Active Comparator |
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| Meal replacement E | Active Comparator |
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| Meal replacement F | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meal replacement | Other | The study interventions contain protein, carbohydrate and fat and are intended for use as complete meal replacements for weight loss. |
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| Measure | Description | Time Frame |
|---|---|---|
| Area under the blood glucose curve (AUC 0-240) | Baseline, 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Area under the insulin curves (AUC 0-240) | Baseline, 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 minutes | |
| Insulinogenic index [Change in Ins30/Change in Glu30] | Baseline, 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joel Neutel, MD | Orange County Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orange County Research Center | Tustin | California | 92780 | United States |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| AUC (0-30min) for insulin | Baseline, 10, 20, 30, 60, 90, 120, 150, 180, 210 and 240 minutes |