Lactobacillus Kefiri LKF01 (DSM32079) in Newborns Born by Caesarian Section

Ability of Lactobacillus Kefiri LKF01 (DSM32079) to Colonize the Intestinal Environment and Modify the Gut Microbiota Composition of Newborns Born by Caesarian Section

The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life.

Probiotics have been observed to positively influence the host's health, but to date few data about the ability of probiotics to modify the gut microbiota composition exist. 40 newborns born by elective caesarian sectional be randomized to a Lactobacillus kefiri LKF01 DSM32079 (LKEF) supplementation or placebo for 21 days. Changes in the gut microbiota composition were detected by using a Next Generation Sequencing technology.

Inclusion Criteria:

• Term newborn
• Adeguate for gestational age
• Born by elective cesarean section
• Otherwise healthy newborn

Exclusion Criteria:

• major acute or chronic disease
• use of probiotics/antibiotics
• gastrointestinal malformation, cystic fibrosis, other genetic diseases
• concurrent participation in other clinical trials