We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.

In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed. We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group. Analyzing the diversity of the fungal and bacterial within colon mucosa between patients with different clinical classification, for example, the proportion of bacteria and fungi, the proportion of candida albicans, the proportion of yeasts, and so on.

Inclusion Criteria:

• Patients at our tertiary care medical center, aged between 18 and 80 years, scheduled to undergo surveillance colonoscopy.
• The patients with ulcerative colitis for ulcerative colitis group.
• The patients without ulcerative colitis for control group.
• 18-80 years.

Exclusion Criteria:

• Using antibiotics, glucocorticoid and immunosuppressants wintin one month.
• There are contraindications for enteroscopy and biopsy.
• There are other intestinal diseases.
• Pregnancy or breast-feeding women.
• Patients with serious lung disease and mental illness.

Consecutive patients under endoscopic surveillance or examination at Qilu Hospital were considered for inclusion.