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| Name | Class |
|---|---|
| The INCLEN Trust International | UNKNOWN |
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This multi-national program applies a breakthrough approach to childhood obesity called, Brain-to-Society (BtS) Diagnostic Approach. In Montreal, Canada and Palwal, India, the investigators will recruit two cohorts of 612 children (6 to 12 years; 306 boy/306 girls) where Whole-of-Society (WoS) transformations are taking place (industrialized societal context with peaking childhood obesity and where a broad governmental plan to promote healthy lifestyle has been adopted -Canada; developing societal context with increasing childhood obesity if replication of past pathways that have lead to double burden; India) are taking place along with World Health Assembly (WHA) resolution A63-12 for marketing of food to children. Individual-level BtS Diagnostic will examine the degree to which individual differences in genetics and biology and differences in the environmental exposures modulate the behavioral, body weight/fatness and nutritional risk over time in the context of WoS transformations. Societal-level BtS Diagnostic shall examine the influence of decisions in policy, investment, business and innovation made by different stakeholders (government, private sector, civil society in health and non-health society systems including agriculture, business and media practices) on the community.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DRD4 and DRD2 Polymorphism Detection | The genetic component of endophenotype for responsiveness to environment (ERE) will be characterized with reference to Taq1A allele in dopamine-2 receptor (DRD2) gene and the exon 3 7-repeat allele of the dopamine-4 receptor (DRD4) gene. This will assist in understanding the role of DRD2 and DRD4 in shaping the neurocognitive functions and link to the eating behaviors of the children and other primary outcome variables. |
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| Measure | Description | Time Frame |
|---|---|---|
| Individual-level BtS Diagnostic 1 | Genotyping and detection of the Taq1A allele in the dopamine-2 receptor (DRD2) gene. | 2 years |
| Individual-level BtS Diagnostic 2 | Genotyping and detection of the exon 3 7-repeat allele of the dopamine-4 receptor (DRD4) gene. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral Assessment | Assess behavior of each participant in relation to food choice | 2 years |
| Body Weight Assessment | Assess body weight of each participant |
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Inclusion Criteria:
Exclusion Criteria:
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In two field settings, Canada (Montreal) and India (Palwal), two cohorts of 612 children (6 to 12 years; 306 boy/306 girls) were recruited. Only one child per family was recruited.
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| Name | Affiliation | Role |
|---|---|---|
| Laurette Dubé, Ph.D. | McGill University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McGill Centre for the Convergence of Health and Economics (MCCHE) | Montreal | Quebec | H3A 1X9 | Canada | ||
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| ID | Type | URL | Comment |
|---|---|---|---|
| Peer-Reviewed Article | View IPD |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D063766 | Pediatric Obesity |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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DNA saliva samples were collected for healthy participants between the ages of 6 and 12 years old before proceeding with genotyping of the 7-repeat risk allele on dopamine-4 receptor (DRD4) gene.
| 2 years |
| Nutritional Risk Assessment | Assess nutrition intake for each participant. | 2 years |
| The INCLEN Trust International |
| New Delhi |
| 110020 |
| India |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |