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The purpose of this prospective intervention study is to find biomarkers and underlying pathomechanisms for non-response of improvement in glucose metabolism to exercise.
An additional goal is to identify non-responders at an early stage, where prevention strategies (pharmacologically or by specific training) will be successful.
At baseline and end of study, an intensive metabolic phenotyping including cerebral insulin sensitivity as well as tissue biopsies are performed in overweight untrained healthy participants at high risk for type 2 diabetes. During the study, an individual exercise training at 80% VO2max is performed for 9 weeks. Before and after the training intervention, acute tissue biopsies after a standardized bout of exercise are obtained.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise training | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| exercise response with respect to changes in insulin sensitivity from baseline to post-intervention measurement | insulin sensitivity is measured before and after the training intervention by a 5-point-75g-OGTT and calculated by ISI Matsuda | 11 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| molecular mechanisms of non-response | molecular mechanisms of non-response in insulin sensitivity in peripheral insulin target tissues (skeletal muscle, adipose tissue) | 11 weeks |
| differences in the adaptation process to exercise in responders versus non-responders |
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Inclusion Criteria:
at least one of the following risk factors for type 2 diabetes:
sedentary participant (< 2 exercise bouts/week)
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hans-Ulrich Häring, Prof. | University Hospital Tuebingen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute for Diabetes research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36134657 | Derived | Kullmann S, Goj T, Veit R, Fritsche L, Wagner L, Schneeweiss P, Hoene M, Hoffmann C, Machann J, Niess A, Preissl H, Birkenfeld AL, Peter A, Haring HU, Fritsche A, Moller A, Weigert C, Heni M. Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese. JCI Insight. 2022 Sep 22;7(18):e161498. doi: 10.1172/jci.insight.161498. | |
| 32827042 |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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by assessing the acute inflammatory response in blood samples and tissue biopsies obtained directly after an acute bout of exercise, at the beginning, and the end of the exercise intervention |
| 11 weeks |
| inflammatory response to exercise | local (muscle and fat) versus systemic (blood) inflammatory response to exercise | 11 weeks |
| changes in brain insulin sensitivity by exercise, and brain differences in responders vs. non-responders | changes in brain insulin sensitivity, before and after the intervention | 11 weeks |
| role of visceral fat mass in determining the non-response of insulin sensitivity to exercise | measured by MRI | 11 weeks |
| identification of serum biomarkers of non-response | 11 weeks |
| Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Haring HU, Weigert C, Moller A. Response of Mitochondrial Respiration in Adipose Tissue and Muscle to 8 Weeks of Endurance Exercise in Obese Subjects. J Clin Endocrinol Metab. 2020 Nov 1;105(11):dgaa571. doi: 10.1210/clinem/dgaa571. |