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| Name | Class |
|---|---|
| HUR Labs | UNKNOWN |
| European Commission | OTHER |
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This trial will take the form of a feasibility study; designed to assess the feasibility of a proposed future clinical trial in this setting. This proposed future clinical trial is proposed to assess the impact of physical activity, in the form of specialised chair based physical activity intervention, on the physiological, psychological, cognitive, social and emotional health, and functional capacity of geriatric populations with pre-existing frailty within a residential care setting; recognising health as a holistic concept incorporating a multitude of inter-related dimensions. This feasibility study is single-centre (taking place at the Olivet Christadelphian care home, 17 Sherbourne Road, Acocks Green, Birmingham, United Kingdom ).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical Activity Intervention | Experimental | HUR resistance training intervention |
|
| Regular care | No Intervention | (Wait-list control) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HUR equipment resistance training intervention | Other | Resistance training intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Feasibility | The primary dependent variables of this feasibility study will relate to the eight primary areas of focus of feasibility studies (Bowen et al. 2009), relating to:
These eight aforementioned areas (all constituting the one variable of feasibility) will serve as the primary dependent variable for this study, in order to establish the feasibility of the proposed future clinical trial within this setting. The dependent variable of feasibility will be assessed through semi-structured interviews with study participants post intervention, while focus groups will be utilised with both the intervention implementers and study support staff in order to assess the primary dependent variable of the study. | Feasibility assessments will occur post-intervention (six-weeks) and during the follow-up (12-weeks), assessing the feasibility of the study from baseline to follow up (12 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Cortisol (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) | |
| Dehydroepiandrosterone-sulphate (DHEAS) (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mr. Paul Doody | Contact | +44 (0) 121 414 | 4125 | p.d.doody@bham.ac.uk |
| Prof. Anna Whittaker | Contact | +44 (0) 121 414 | 4398 | a.c.whittaker@bham.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Prof. Anna Whittaker | University of Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Olivet Christadelphian care home, 17 Sherbourne Road, Acocks Green, Birmingham, United Kingdom | Birmingham | West Midlands | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19362699 | Background | Bowen DJ, Kreuter M, Spring B, Cofta-Woerpel L, Linnan L, Weiner D, Bakken S, Kaplan CP, Squiers L, Fabrizio C, Fernandez M. How we design feasibility studies. Am J Prev Med. 2009 May;36(5):452-7. doi: 10.1016/j.amepre.2009.02.002. | |
| 38262397 | Derived | Swales B, Ryde GC, Whittaker AC. A Mixed Methods Feasibility Study of Machine-Based Resistance Training With Prefrail Older Adults in Residential Care: The Keeping Active in Residential Elderly Trial II. J Aging Phys Act. 2024 Jan 23;32(2):244-263. doi: 10.1123/japa.2022-0170. Print 2024 Apr 1. |
| Label | URL |
|---|---|
| Physical Activity and Nutritional INfluences In ageing (PANINI) project website | View source |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
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| Serum cortisol: DHEAS ratio (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| C-Reactive proteins (CRP) (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Inflammatory cytokine: Interleukin 6 (IL-6) (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Inflammatory cytokine: Tumor Necrosis Factor alpha (TNFα) (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Inflammatory cytokine: Interferon gamma (IFNy) (Physiological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Handgrip strenght (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Leg Strength (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Leg power output (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Short Physical Performance Battery (SPPB) (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Katz Index of Independence in Activities of Daily Living (Katz ADL) (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Fried Frailty Phenotype (Functional Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Geriatric Depression Scale (GDS) (Psychological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Hospital Anxiety Depression Scale (HADS) (Psychological Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Psychological Dependent Variable: Perceived Stress Scale (PSS) (Psychological Dependent Variable | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Standardized Mini-Mental State Examination (SMMSE) (Cognitive Dependent Variable) | Standardized Mini-Mental State Examination (SMMSE) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| Interpersonal Support Evaluation List (Social Dependent Variable) | Pre-intervention (baseline), and post-intervention (six-weeks), follow-up (12-weeks) |
| 38066459 | Derived | Swales B, Ryde GC, Fletcher I, Whittaker AC. The reliability and suitability of strength assessments in frail and pre-frail older adults: recommendations for strength testing in older populations. BMC Geriatr. 2023 Dec 8;23(1):820. doi: 10.1186/s12877-023-04552-3. |
| 34510020 | Derived | Swales B, Ryde GC, Whittaker AC. A Randomized Controlled Feasibility Trial Evaluating a Resistance Training Intervention With Frail Older Adults in Residential Care: The Keeping Active in Residential Elderly Trial. J Aging Phys Act. 2022 Jun 1;30(3):364-388. doi: 10.1123/japa.2021-0130. Epub 2021 Sep 11. |
| 31321070 | Derived | Doody P, Lord JM, Whittaker AC. Assessing the feasibility and impact of an adapted resistance training intervention, aimed at improving the multi-dimensional health and functional capacity of frail older adults in residential care settings: protocol for a feasibility study. Pilot Feasibility Stud. 2019 Jul 5;5:86. doi: 10.1186/s40814-019-0470-1. eCollection 2019. |
| Physical Activity and Nutritional INfluences In ageing (PANINI) project twitter | View source |