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Orocecal transit time is studied in individuals with irritable bowel syndrome (IBS) of both the constipation-dominant, diarrhea-dominant, and mixed form using the lactulose hydrogen breath test for orocecal transit time through the gut. Data are compared to those of healthy volunteers. The peak value of fermentation as read by hydrogen levels is captured after passage of the orocecal segment in the colon. Comparison are made between IBS patients and healthy subjects as regards orocecal transit time and peak fermentation in the cecum.
Patients with IBS of various kind (constipation-dominant, diarrhea-dominant, and mixed form) in large numbers are studied as regards orocecal transit time and compared to healthy controls.
Inclusion criteria: IBS patients 18-80 years old, diagnosis of IBS; exclusion: Severe cardiac, pulmonary, liver or kidney disease, bloody stool After fasting for 12 hours, all subjects ingest 10 grams of lactulose. Hydrogen production, measured as hydrogen concentration in breath, is estimated at 10-minute intervals for a period of 240 minutes. The orocecal transit transit time is measured from ingestion of the lactulose solution until hydrogen peaks to 10 and 20 ppm when passing the ileocecal valve, being fermented by the cecal microflora. Data are compared to those of healthy volunteers.
The peak value of fermentation as read by hydrogen levels (ppm) captured after passage of the ilecocecal valve orocecal valve signifies the gas production of the micro13flora. Comparison are made between IBS patients and healthy subjects as regards orocecal transit time and peak fermentation in the cecum.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Normal subjects aged 18-80 years. No chronic diseases. |
| |
| IBS patients, lactose intolerant | Subjects 18-80 years diagnosed with IBS for more than 6 months ago; lactose intolerant. No concomitant diseases. |
| |
| IBS patients, lactose tolerant | Subjects 18-80 years diagnosed with IBS for more than 6 months ago; lactose tolerant. No concomitant diseases. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactulose breath test | Diagnostic Test | Lactulose 0.67 mg/mL, dose 15 mL (10 grams). No contaminants of lactose. Pharmacy quality. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Orocecal transit time | The transit rate of lactulose (foods) through the small intestine | 0-240 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Fermentation of lactulose of the cecal microbiota measured as increase of hydrogen in exhaled breath. | The rise of hydrogen (beyond 10 and 20 ppm) after lactulose passing the ileo-cecal valve. | 0-240 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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IBS patients aged 18-80 years of age as recruited in the clinic, some of which are lactose intolerant, others are lactose tolerant.
Healthy volunteers 18-80 years of age as recruited in society in daily life activities.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Per M Hellstrom, MD, PhD | Contact | +46703727423 | Per.Hellstrom@medsci.uu.se | |
| Peter Benno, MD, PhD | Contact | +46705795554 | Peter.Benno@endoskopienheten.se |
| Name | Affiliation | Role |
|---|---|---|
| Per M Hellstrom, MD, PhD | Uppsala University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uppsala University | Recruiting | Uppsala | Uppsala County | 75185 | Sweden |
Data are freely available to anyone. Data coded.
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