Influence of Genetic Polymorphism of Donor on Tacrolimus Concentration in Liver Transplant

The Influence of ABCB1、CYP3A4、CYP3A5、POR Genetic Polymorphism of Donor on Tacrolimus Blood Concentration in Liver Transplant Patients

To study the influence of donor's ABCB1、CYP3A4、CYP3A5、POR genetic polymorphism on tacrolimus blood concentration in liver transplant recipients.

This study will start with a retrospective data analysis. The investigators will use the electronic databases of National Taiwan University Hospital to identify patients who underwent liver transplantation, received tacrolimus and were still followed up at the outpatient clinic. Inclusion and exclusion criteria will be applied to screen appropriate participants, and find their donors. And analyze the effect of genetic polymorphism (ABCB1、CYP3A4、CYP3A5、POR) of donors, including other factors of recipients, on the dose normalized trough concentration of tacrolimus.

Inclusion Criteria:donors' recipients

• Living liver transplant during 20070101 ~ 20151231 and only received liver transplantation
• Lab data at least 8 months,
• Receiving tacrolimus as immunosuppressive drugs
• Transplantation at 20 ~ 65 years old

Exclusion Criteria: donors' recipients

• Retransplantation or multi-organ transplantation
• Non-Asian
• Positive for human immunodeficiency virus.