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| Name | Class |
|---|---|
| Universität Tübingen | OTHER |
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The prenylflavonoids 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN) are secondary plant substances, almost exclusively found in hops (Humulus lupulus). Both compounds have known potential biological properties, but poor bioavailability due to their low oral absorption and retention. Our study followed a single dose (500 mg 6- or 8-PN), placebo controlled, randomized, double-blind, three armed crossover study design with ≥2-week washout periods. Plasma, PBMC and urine samples were collected at intervals up to 24 h after intake. Investigators investigated the safety, pharmacokinetics and impact of oral prenylflavonoids on the function of cells of the immune system.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Capsules filled with mannitol and silicon dioxide |
|
| 6-prenylnaringenin | Experimental | 500 mg 6-PN plus mannitol and silicon dioxide |
|
| 8-prenylnaringenin | Experimental | 500 mg 8-PN plus mannitol and silicon dioxide |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Dietary Supplement |
| ||
| 6-prenylnaringenin |
| Measure | Description | Time Frame |
|---|---|---|
| Mean area under the curve (AUC) of plasma concentration vs. time of total 6-prenylnaringenin [nmol/L*h] | Total 6-PN after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Mean area under the curve (AUC) of plasma concentration vs. time of total 8-prenylnaringenin [nmol/L*h] | Total trans-epsilon-viniferin after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Mean maximum plasma concentration (Cmax) of total 6-prenylnaringenin [nmol/L] | Total trans-resveratrol after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Mean maximum plasma concentration (Cmax) of total 8-prenylnaringenin [nmol/L] | Total trans-epsilon-viniferin after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Time to reach maximum plasma concentration (Tmax) of total 6-prenylnaringenin [h] | Total trans-resveratrol after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Time to reach maximum plasma concentration (Tmax) of total 8-prenylnaringenin [h] | Total trans-epsilon-viniferin after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Cumulative urinary excretion of total 6-prenylnaringenin [nmol/g creatinine] |
| Measure | Description | Time Frame |
|---|---|---|
| Serum aspartate transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum alanine transaminase activity [U/L] | 0, 4, 24h post-dose | |
| Serum gamma-glutamyl transferase activity [U/L] |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jan Frank, Prof. Dr. | University of Hohenheim | Principal Investigator |
| Sascha Venturelli, Dr. med. Dr. rer. nat. | Eberhard Karls University Tuebingen | Principal Investigator |
| Christian Busch, Dr. med. | Eberhard Karls University Tuebingen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Hohenheim | Stuttgart | Baden-Wurttemberg | 70599 | Germany | ||
| Eberhard Karls University Tuebingen |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29363261 | Derived | Calvo-Castro LA, Burkard M, Sus N, Scheubeck G, Leischner C, Lauer UM, Bosy-Westphal A, Hund V, Busch C, Venturelli S, Frank J. The Oral Bioavailability of 8-Prenylnaringenin from Hops (Humulus Lupulus L.) in Healthy Women and Men is Significantly Higher than that of its Positional Isomer 6-Prenylnaringenin in a Randomized Crossover Trial. Mol Nutr Food Res. 2018 Apr;62(7):e1700838. doi: 10.1002/mnfr.201700838. Epub 2018 Mar 1. |
| Label | URL |
|---|---|
| Website of the research group | View source |
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| ID | Term |
|---|---|
| C521871 | 6-prenylnaringenin |
| C119737 | 8-prenylnaringenin |
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|
|
| 8-prenylnaringenin | Dietary Supplement |
|
|
Total trans-resveratrol after deconjugation with beta-glucuronidase/sulphatase |
| 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Cumulative urinary excretion of total 8-prenylnaringenin [nmol/g creatinine] | Total trans-epsilon-viniferin after deconjugation with beta-glucuronidase/sulphatase | 0, 0.5, 1, 2, 4, 6, 8 and 24 h post dose |
| Cell count (dead cells/ml and living cells/ml) of PBMCs after 6-PN administration | 0, 6, and 24 h post dose |
| Cell count (dead cells/ml and living cells/ml) of PBMCs after 8-PN administration | 0, 6, and 24 h post dose |
| Cell viability of PBMCs after 6-PN administration | 0, 6, and 24 h post dose |
| Cell viability of PBMCs after 8-PN administration | 0, 6, and 24 h post dose |
| 0, 4, 24h post-dose |
| Serum alkaline phosphatase activity [U/L] | 0, 4, 24h post-dose |
| Serum bilirubin | 0, 4, 24h post-dose |
| Serum uric acid [mg/dL] | 0, 4, 24h post-dose |
| Serum creatinine [mg/dL] | 0, 4, 24h post-dose |
| Serum total cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum HDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum LDL cholesterol [mg/dL] | 0, 4, 24h post-dose |
| Serum triacylglycerols [mg/dL] | 0, 4, 24h post-dose |
| LDL/HDL cholesterol ratio | 0, 4, 24h post-dose |
| Serum cystatin C [mg/mL] | 0, 4, 24h post-dose |
| Glomerular filtration rate [mL/min] | 0, 4, 24h post-dose |
| Serum glucose [mg/dL] | 0, 24h post-dose |
| Hemoglobin [g/dL] | 0, 24h post-dose |
| Mean corpuscular hemoglobin concentration [g/dL] | 0, 24h post-dose |
| Mean corpuscular hemoglobin [pg] | 0, 24h post-dose |
| Mean corpuscular volume [fL] | 0, 24h post-dose |
| Hematocrit [%] | 0, 24h post-dose |
| Erythrocytes [/pL] | 0, 24h post-dose |
| Thrombocytes [/nL] | 0, 24h post-dose |
| Leucocytes [/nL] | 0, 24h post-dose |
| Segmented granulocytes [%] | 0, 24h post-dose |
| Lymphocytes [%] | 0, 24h post-dose |
| Monocytes [%] | 0, 24h post-dose |
| Basophil granulocytes [%] | 0, 24h post-dose |
| Eosinophil granulocytes [%] | 0, 24h post-dose |
| Tübingen |
| Baden-Wurttemberg |
| 72076 |
| Germany |