Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT [ULD-CT] and Conventional Chest Radiography [CXR]

Screening for Pneumonia: A Comparison of Ultra Low Dose Chest CT and Conventional Chest Radiography

The ULTRACHEST study will be a prospective clinical diagnostic performance study with primary objective to establish device diagnostic clinical performance of Ultra Low Dose CT (ULD-CT) in order to prove it is more accurate in detecting pneumonia when comparing to standard conventional chest radiography.

• 200 subjects
• Each subject will undergo CXR and ULD-CT at the same day.
• Subjects subdivided into 3 groups [high, moderate and low risk], based on a laboratory finding(CRP), symptoms and physical examination.
• 3 different thoracic radiologist will judge the scans on existence of consolidation. Consolidation will be expressed as binary outcomes (Yes or No consolidation)
• Radiologist will be blinded for subjects demographic data.
• All radiologist have to score how confidence they were on the finding of consolidation[5point likert].
• The investigators will perform a McNemar's test for evaluation. A two sided p-value of less than 0.05 will be considered to be statistically significant.
• Inter-observer variability will be evaluated by using a Fleiss Kappa test.

Inclusion Criteria:

• Suffering from pneumonia and referred by their GP

Exclusion Criteria:

• Younger than 18
• Known pregnancy
• Not able to sign the Informed Consent document
• If not willing to be informed about additional findings