Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases

Retrospective Observational Study on the Safety of Immune Checkpoint Inhibitors in the Treatment of Advanced Melanoma and Lung Cancers in Patients With Pre-Existing Autoimmune Diseases

The tolerance of immune checkpoint inhibitors is unknown in patients with pre-existing autoimmune conditions. This retrospective nation-wide study will assess their tolerance in patients with pre-existing autoimmune conditions who received immune checkpoint inhibitors for an advanced cancer in clinical practice.

Inclusion Criteria:

• Pre-existing autoimmune disease as diagnosed by the physician
• Immune checkpoint inhibitor therapy for an advanced cancer

Exclusion Criteria:

• Auto-immune disease developed only after the start of the immune checkpoint inhibitor therapy
• Absence of follow-up