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In this study, investigators want to find the effect of adjuvant collagen cross-linking in the treatment of fungal keratitis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional treatment | Experimental | In this arm, patients with documented fungal keratitis undergo conventional medical treatment. |
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| conventional treatment +CXL | Active Comparator | In this arm, patients with documented fungal keratitis undergo conventional medical treatment plus CXL, beginning on the first day |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| topical voriconazole / levofloxacin systemic itraconazole | Drug | starting topical voriconazole every hour tapering after 4 days , levofloxacin every 6 hours, Itraconazole 100mg /BD for 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| time of complete healing (days) | time to scar formation (days) | 180 days |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32557558 | Derived | Davis SA, Bovelle R, Han G, Kwagyan J. Corneal collagen cross-linking for bacterial infectious keratitis. Cochrane Database Syst Rev. 2020 Jun 17;6(6):CD013001. doi: 10.1002/14651858.CD013001.pub2. |
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| ID | Term |
|---|---|
| D065819 | Voriconazole |
| ID | Term |
|---|---|
| D014230 | Triazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| CXL | Radiation | 30 min Riboflavin prescription to the cornea followed by 30 min UV-A radiation at 3mW/cm2 associated with Riboflavin administration |
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