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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| Redlich Pain Endowment | UNKNOWN |
| Rocky Mountain Foundation | UNKNOWN |
| The Feldman Family Foundation Pain Research Fund |
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The aim of the current study is to assess the efficacy of TMS in the treatment of Complex Regional Pain Syndrome (CRPS). It is hypothesized that participants who receive TMS (Group 1) relative to sham treatment (Group 2) once daily for two days will demonstrate a greater improvement in CRPS-related pain and other associated symptomology (i.e., cognitive, emotional and physical) compared to baseline. Participants will be followed until they reach their baseline for two consecutive weeks to assess safety and duration of symptom alleviation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active Treatment | Experimental | Participants will receive active TMS in the target area once daily for two days |
|
| Sham Treatment | Sham Comparator | Participants will receive active TMS in a non-target area once daily for two days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation (TMS) | Device | The Magventure TMS stimulator will be used to perform intermittent theta burst followed by high frequency Transcranial Magnetic Stimulation (TMS). |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pain | Decrease in CRPS-related Pain Ratings | 1 week follow-up compared to baseline |
| Duration of Pain Relief | Duration of decreased CRPS-related pain ratings, measured as a length of time until pain returns for two consecutive weeks | Duration from last treatment until pain returns - up to an estimate of 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pain-related Symptomology | Decreases in Pain-related Symptomology (i.e., cognitive, emotional and physical) | Duration from last treatment until pain returns - up to an estimate of 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Omar Altirkawi | Contact | (650) 497-0485 | omar97@stanford.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford Pain Management Center | Recruiting | Redwood City | California | 94043 | United States |
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| ID | Term |
|---|---|
| D020918 | Complex Regional Pain Syndromes |
| ID | Term |
|---|---|
| D001342 | Autonomic Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| UNKNOWN |
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Single, blinding of participant