Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.

The current project will result in the identification of genetic, environmental or downstream biomedical markers that predict the development of celiac disease at the individual level. Moreover, the markers can be exploited in prediction of specific disease risks, manifestations, comorbidities and complications.

Inclusion Criteria:

• Cohort 1: Family member of celiac disease patient
• Cohort 2: Previously diagnosed celiac disease

Exclusion Criteria:

• Cohort 1: No previous celiac disease
• Cohort 2: Celiac disease diagnosis not confirmed

Volunteers; cohort 1, 3217 genetically predisposed healthy family members of celiac disease patients (high risk group for celiac disease), Cohort 2, 200 new celiac disease index cases will be enrolled