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The goal is to establish another anatomical referencing system in order to achieve an even higher accuracy when implanting stimulation electrodes.
The main goal is to find out what are the optimal distances to these reference fiber tracts when stimulating and to find the optimal target. This has to be evaluated for each target, such as globus pallidus (Gpi), subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM) separately. This is of special importance as the investigators can demonstrate the internal capsule, which is often a generator of stimulation-induced side effects: tetanic muscle contractions, dysarthria and gaze deviations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subthalamic Nucleus (STN) | Patients with Parkinson's disease |
| |
| Globus Pallidus (Gpi) | Patients with Dystonia |
| |
| Ventral intermediate nucleus of the thalamus (VIM) | Patients with Tremor |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Deep Brain Stimulation | Procedure | Deep Brain Stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| distance between stimulation electrode and motor fibers in mm | Distances between the stimulation electrode and motor fibers as depicted on fiber tracking in millimeters in correlation to the threshold current for eliciting clinical side effects | Intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative intensity of stimulation in milliampere (mA) | Intraoperative intensity of stimulation in milliamp, which elicits an activation of contralateral muscle groups (musculus interosseus dorsalis and the musculus tibialis anterior) | Intraoperative |
| Stimulation thresholds in milliampere (mA) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who qualify for deep brain stimulation on the basis of a movement disorder and chronic pain
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lutz Weise, MD | Contact | 902-473-6850 | lutz.weise@nshealth.ca |
| Name | Affiliation | Role |
|---|---|---|
| Lutz Weise, MD | Dalhousie University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen Elizabeth Health Science Centre | Recruiting | Halifax | Nova Scotia | B3H3A7 | Canada |
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| ID | Term |
|---|---|
| D046690 | Deep Brain Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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Threshold of intraoperative stimulation intensity in milliamp, which elicits capsular side effects |
| Intraoperative |
| Change in disease score units on the UPDRS rating scale | Assessment of therapeutic effects using Unified Parkinson disease rating scale (UPDRS) | twelve months |
| Change in disease score units on the FTRS rating scale | Assessment of therapeutic effects using, Fahn-Tremor Rating Scale (FTRS) | twelve months |
| Change in disease score units on the BFMDRS rating scale | Assessment of therapeutic effects using Burke-Fahn-Marsden dystonia rating scale (BFMDRS) | twelve months |
| Change in disease score units on the TWSTR rating scale | Assessment of therapeutic effects using Toronto Western Spasmodic torticollis rating scale (TWSTR) | twelve months |
| Change in disease score units on the PDQ-39 rating scale | Assessment of therapeutic effects using Parkinsons Disease QuestionnairePDQ-39 | twelve months |