To assess the functional characteristics and utility of upper and lower limb prosthetic devices (advanced bionic and current clinical standard-of-care) that incorporate physiologically relevant touch and/or movement feedback.

Inclusion Criteria:

Inclusion criteria are adults (18 years or over) with major limb amputation (at or above wrist or ankle).

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Exclusion Criteria:

Exclusion criteria are any skin or pain conditions that would preclude ability to withstand pressures on their limb or to wear a prosthetic socket, or cognitive barriers precluding providing informed consent.

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Significant scientific results and data will be shared. Final data sets will include information such as survey results, de-identified aggregate data of prosthetic users' abilities and functional outcomes, de-identified photographic/video. Non-proprietary/non-identifying data and findings will be disseminated in a timely manner through scientific seminars, meetings, and peer reviewed publications.

Data will be shared within the 4-year time frame following the end of active protocols.

Data will be shared under the auspices of the principal investigator and data sharing will be done through a Cleveland Clinic issued, firewall protected FTP network server. Although the final data set will be stripped of identifiers, the possibility of deductive disclosure remains. Data/documentation will be available only under data-sharing agreements that provide for: (1) a commitment to data use only for research purposes only and non-identification of individuals; (2) a commitment to data security with using appropriate technology; and (3) a commitment to destroying/returning data after completed analyses.