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: Inflammatory bowel diseases (IBD), such as Crohn's disease (CD) and ulcerative colitis (UC) need long term treatments which can conflict with a desire of pregnancy in women. Uncontrolled IBD increases the risk of poor pregnancy outcomes [1]. Antitumor Necrosis Factor α (antiTNFα) are commonly used, off-label, in pregnancy but with the risk of treatment-related complications. Existing recommendations on the use of antiTNFα during pregnancy are conflicting and only rely on expert opinions. This study was aimed to assess appropriateness and risk to benefit ratio of antiTNFα treatment during pregnancy in women with IBD, for both the mother and the baby until the end of the first year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pregnant IBD women treated | pregnant IBD women treated by antiTNFα |
| |
| pregnant IBD women not treated | pregnant IBD women not treated by antiTNFα |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| treated by antiTNFα | Other | pregnant IBD women treated by antiTNFα |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Overall complications | composite criteria composed by:
| 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Infectious Complications in the children born from IBD mothers | Occurrence of infectious complications during the first year of life | The first year of life |
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Inclusion Criteria:
Exclusion Criteria:
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All pregnant women with a diagnosis of IBD
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chu de Dijon | Dijon | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29961771 | Result | Luu M, Benzenine E, Doret M, Michiels C, Barkun A, Degand T, Quantin C, Bardou M. Continuous Anti-TNFalpha Use Throughout Pregnancy: Possible Complications For the Mother But Not for the Fetus. A Retrospective Cohort on the French National Health Insurance Database (EVASION). Am J Gastroenterol. 2018 Nov;113(11):1669-1677. doi: 10.1038/s41395-018-0176-7. Epub 2018 Jul 2. |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| not treated by antiTNFα |
| Other |
pregnant IBD women not treated by antiTNFα |
|