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| Name | Class |
|---|---|
| University of East Anglia | OTHER |
| University of Manchester | OTHER |
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The purpose of this study is to examine the effect of vitamin D supplementation on vitamin D status, immunity and physical performance.
Vitamin D plays a key role in bone mineralisation and has been linked to immune defence maintenance and muscle function. Vitamin D is primarily obtained from endogenous synthesis in response to skin sunlight exposure and follows a seasonal pattern; whereby, vitamin D levels peak at the end of the summer and fall to a trough during winter. If winter vitamin D levels can be increased to match those found in summer using supplementation, it is proposed sufficient vitamin D levels will improve physical performance and reduce susceptibility to illness in military recruits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Solar simulated radiation (SSR) | Experimental | Solar simulated radiation (SSR) |
|
| Placebo SSR | Placebo Comparator | Placebo SSR |
|
| Oral Vitamin D3 | Experimental | Oral Vitamin D3 |
|
| Placebo Oral Vitamin D3 | Placebo Comparator | Placebo Oral Vitamin D3 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral Vitamin D3 | Dietary Supplement |
| ||
| Placebo Oral Vitamin D3 |
| Measure | Description | Time Frame |
|---|---|---|
| Vitamin D status | Circulating 25-hydroxy-vitamin D, 1,25-d OH(OH)D | Up to 20 months |
| Measure | Description | Time Frame |
|---|---|---|
| Physical performance 1 | Vertical Jump height (cm) and peak power output (watts) | Up to 20 months |
| Physical performance 2 | Maximal dynamic lift strength (kg) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Prof Neil Walsh, PhD | Contact | 01248 | 383480 | n.walsh@bangor.ac.uk |
| Dr Julie Greeves, PhD | Contact | 01264 | 886827 | ArmyMed-SHA-APRC-ResDir@mod.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Infantry Training Centre | Recruiting | Catterick | North Yorkshire | DL9 3PS | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32390123 | Derived | Kashi DS, Oliver SJ, Wentz LM, Roberts R, Carswell AT, Tang JCY, Jackson S, Izard RM, Allan D, Rhodes LE, Fraser WD, Greeves JP, Walsh NP. Vitamin D and the hepatitis B vaccine response: a prospective cohort study and a randomized, placebo-controlled oral vitamin D3 and simulated sunlight supplementation trial in healthy adults. Eur J Nutr. 2021 Feb;60(1):475-491. doi: 10.1007/s00394-020-02261-w. Epub 2020 May 10. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 3, 2020 | |
| Reset | Feb 13, 2020 | |
| Release | Feb 14, 2025 | |
| Unrelease | Feb 14, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 3, 2020 | Feb 13, 2020 | |||
| Feb 14, 2025 | Feb 14, 2025 |
| ID | Term |
|---|---|
| D014808 | Vitamin D Deficiency |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Dietary Supplement |
|
| Solar simulated radiation (SSR) | Radiation |
|
| Placebo SSR | Radiation |
|
| Up to 20 months |
| Physical performance 3 | Multi-stage fitness test predicted VO2max (mL/kg/min) | Up to 20 months |
| Hepatitis B antibody | Antibody produced in response to the presence of Hepatitis B antigen (e.g. Hepatitis B vaccine) | Up to 20 months |
| Mucosal immunity | Secretory Immunoglobulin A levels | Up to 20 months |
| D009750 |
| Nutritional and Metabolic Diseases |
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |