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Right-sided colonic cancer is treated with right-sided colectomy, predominantly performed as minimally invasive surgery with extracorporeal anastomosis (ECA). In recent years a new technique with intracorporeal anastomosis (ICA) has emerged and it is thought that ICA is less invasive and thereby has the potential to improve the postoperative course of right colonic cancer patients.
The objective of this study is to compare robotic right colectomy with either ICA or ECA in a randomized controlled setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intracorporeal anastomosis | Experimental | Patients undergo robotic right colectomy with intracorporeal anastomosis. |
|
| Extracorporeal anastomosis | Active Comparator | Patients undergo robotic right colectomy with extracorporeal anastomosis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intracorporeal anastomosis | Procedure | Use of intracorporeal anastomosis technique |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative recovery | Questionnaire of Recovery 15 (QoR-15) | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Time fo first flatus | 1 month | |
| Time to first bowel movement | 1 month | |
| Length of hospital stay |
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Inclusion Criteria:
All patients scheduled for robotic right colectomy due to colonic cancer are eligible for inclusion.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herlev Hospital | Herlev | Copenhagen | Denmark | |||
| Sealand University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36171282 | Derived | Dohrn N, Oppermann C, Yikilmaz H, Laursen M, Khesrawi F, Clausen FB, Jakobsen HL, Brisling S, Lykke J, Eriksen JR, Klein MF, Gogenur I. The effect of intracorporeal versus extracorporeal anastomosis in robotic right colectomy on perianastomotic perfusion: a substudy to a multicenter RCT. Langenbecks Arch Surg. 2022 Dec;407(8):3577-3586. doi: 10.1007/s00423-022-02693-4. Epub 2022 Sep 28. | |
| 35129520 |
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| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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Randomized controlled trial
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| Extracorporeal anastomosis | Procedure | Use of the conventional extracorporeal anastomosis technique |
|
| 1 month |
| Morbidity | 1 month |
| Mortality | 1 month |
| Postoperative pain | 1 month |
| Heart Rate Variability | Continuously ECG-monitoring intraoperatively and postoperatively | 2 days |
| "Timed up and go"-test | 2 days |
| Ortostatic hypotension test | 2 days |
| Spirometry and PEF - test | Postoperative pulmonary function | 2 days |
| Postoperative opioid usage | 1 month |
| Whole blood gene expression profiling | Measuring changes in expression of ROS and immulogical genes due to surgery. | 1 month |
| Roskilde |
| Denmark |
| Derived |
| Dohrn N, Yikilmaz H, Laursen M, Khesrawi F, Clausen FB, Sorensen F, Jakobsen HL, Brisling S, Lykke J, Eriksen JR, Klein MF, Gogenur I. Intracorporeal Versus Extracorporeal Anastomosis in Robotic Right Colectomy: A Multicenter, Triple-blind, Randomized Clinical Trial. Ann Surg. 2022 Nov 1;276(5):e294-e301. doi: 10.1097/SLA.0000000000005254. Epub 2021 Oct 13. |
| 33913415 | Derived | Dohrn N, Klein MF, Gogenur I. Intracorporeal versus extracorporeal anastomosis in right colectomy - a protocol for a randomised trial. Dan Med J. 2021 Apr 20;68(5):A09200710. |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |