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After an interim analysis, it was decided to discontinue the study after a stochastic curtailment analysis.
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The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.
Effects of ovarian stimulation on human embryo quality is still a subject of study. When natural and stimulated cycles have been compared, no differences have been observed in terms of embryo cleavage capacity, oocyte and embryo aneuploidy rate or incidence of aneuploidy in aborted foetuses. When mild and conventional doses of gonadotropins have been compared, a higher proportion of good morphological quality embryos are observed in the former. On the contrary, we showed that ovarian stimulation does not increase significantly the embryo aneuploidy rate in IVF derived human embryos when unstimulated and stimulated cycles were compared in oocyte donors. In this study, we want to compare the embryo aneuploidy rate between unstimulated and stimulated cycles in infertile patients, subjected to both IVF cycles with blastocyst biopsy and NGS-PGS. A comparison of the morphokinetics will also be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Natural Cycle | The patient will not undergo hyperstimulation rather a natural cycle | ||
| Stimulated Cycle | The 80 patients will undergo hyperstimulation cycle as per the clinical practice planned for the patient. |
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| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the number of euploid embryos from Metaphase II oocytes in different cohorts of embryos. | Number of metaphase II oocyte per euploid embryo in unstimulated and stimulated cycles. | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of embryo aneuploidies in two cohorts of embryos. | Incidence of embryo aneuploidies between the unstimulated and stimulated cycle in the same patient | 30 days |
| Morphokinetic evaluation of embryos in two different cohorts of embryos. |
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Inclusion Criteria:
Exclusion Criteria:
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Women undergoing fertility treatment
Women undergoing In Vitro Fertilization treatment
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IVI Valencia | Valencia | 46003 | Spain | |||
| Instituto Valenciano de Infertilidad Spain |
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Morphokinetic evaluation of the embryos obtained in an unstimulated and stimulated cycle
| 30 days |
| Valencia |
| 46015 |
| Spain |
| IVI Valencia | Valencia | 46015 | Spain |