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Evaluation of clinical outcome and economical aspects in the treatment of patients with peritoneal carcinomatosis.
Peritoneal carcinomatosis is a dooming finding with no hope for cure and a steadily decrease in quality of life. Cytoreductive surgery with intraperitoneal chemotherapy (CRS HIPEC) offers a small but proven chance for cure. The implementation of a CRS HIPEC and PIPAC programme in a Swiss tertiary care hospital is evaluated.
When a patient is deemed non resectable, pressurized intraperitoneal aerosol chemotherapy (PIPAC) administered laparoscopically may confer effective palliation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRS and intraoperative chemotherapy | Patients receiving cytoreductive surgery and intraoperative chemotherapy (HIPEC/PIPAC) |
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative surgical complications | Reporting and grading of postoperative surgical complications (according to Dindo) | 90 days |
| Rehospitalisation | Rehospitalisation: (yes/no), time frame, cause of rehospitalisation | 90 days |
| Disease-free survival | Time to recurrence measured since diagnosis/Intervention (in months) | 5 years |
| Overall Survival | All cause mortality since diagnosis/Intervention (in months) | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of quality of life | Validated measurements of health-related quality of life according to the EORTC manual in terms of general quality of life: EORTC-QLQ30; disease-specific quality of life: EORTC-CR29 (colorectal cancers), and health-utility (EQ-5D). | 5 years |
| Cost |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with peritoneal carcinomatosis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michel Adamina, Prof/MD/MSc | Contact | +41522663634 | Michel.Adamina@ksw.ch | |
| Kantonsspital Winterthur | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Michel Adamina, Prof/MD/MSc | Kantonsspital Winterthur KSW | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kantonsspital Winterthur | Recruiting | Winterthur | Canton of Zurich | 8401 | Switzerland |
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| ID | Term |
|---|---|
| D010534 | Peritoneal Neoplasms |
| ID | Term |
|---|---|
| D000008 | Abdominal Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004067 | Digestive System Neoplasms |
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At the level of individual patient Cost in terms of hospital charges and expenses in Swiss Francs |
| 90 days |
| Revenues | At the level of individual patient Revenues in Swiss Francs as billed according to the DRG and case-mix index | 90 days |
| Cost-utility analysis | Calculation and comparison of QUALY (quality-adjusted life years derived from EQ-5D) for competing treatment strategies taking advantage of published figures and own data, e.g. cost of a systemic palliative chemotherapy compared to cost of an intraperitoneal chemotherapy | 90 days |
| Cost-effectiveness | Aggregation of costs, charges, and revenues for the whole series and comparison with alternative treatment option as clinically relevant, chemotherapy alone and palliative surgery alone. | 90 days |
| D004066 |
| Digestive System Diseases |
| D010532 | Peritoneal Diseases |