Interventions for Postoperative Delirium: Biomarker-3

Interventions for Postoperative Delirium: Biomarker-3

The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.

Inclusion Criteria:

• Cohort 1: Age ≥65 years
• Cohort 2: Age ≥60 years
• Anticipated length of hospital stay of at least 2 days after surgery that occurs under general or neuraxial anesthesia
• Written Informed Consent for potential participation prior to surgery

Exclusion Criteria:

• Contraindication to EEG
• Unable or unwilling to attend the follow-up appointments
• Documented history of dementia
• Deemed incapable of providing consent by surgical team
• Residing in a nursing home
• Undergoing intracranial surgery
• Unable to complete neurocognitive testing due to language, vision or hearing impairment
• Unable to communicate with the research staff due to language barriers
• For optional MRI portion of the study: Contraindication to MRI (e.g., implanted devices not safe for MRI studies, claustrophobia, unable to lie flat or still)