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The purpose of the study is to evaluate if metformin is taken up into the failing myocardium. Recent experimental and epidemiological studies have shown beneficial effects of metformin on heart failure. It is unknown whether this effect is direct or indirect.
The aim of the study is to investigate if metformin is taken up in heart failure using a novel 11C-metformin tracer and positron emission tomography (PET).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 11C-metformin | Experimental | All participants allocated to the study will be included in this arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 11C-metformin | Radiation | 200 MBq of 11C-metformin is injected in the cubital vein. The participant is then scanned for 120 min using Positron Emission Tomography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metformin uptake in the failing myocardium | Cardiac uptake is evaluated through analysis of acquired PET-images. | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University Hospital, Department of Cardiology, Palle Juul-Jensens Boulevard 99 | Aarhus N | 8200 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41711740 | Derived | Larsen AH, Lin L, Moller AB, Farup J, Tolbod LP, Billeskov T, Brorson J, Sundelin EIO, Jakobsen S, Norrelund H, Harms HJ, Hansson NH, Pedersen SB, Gormsen LC, Luo Y, de Paoli FV, Frokiaer J, Wiggers H, Jessen N. Metformin inhibits proliferation of residing fibroadipogenic progenitor cells from failing human hearts. ESC Heart Fail. 2026 Feb 3;13(1):xvag001. doi: 10.1093/eschf/xvag001. |
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| ID | Term |
|---|---|
| D054143 | Heart Failure, Systolic |
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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All 6 subjects allocated to the study will receive 11C-metformin intravenously.
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Open label
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