It is not known whether radiological assessments during follow up after surgery for high risk melanoma improve survival. Since radiological examinations are resource demanding, could inflict worry and cause irradiation exposure it is an important question to address. With the introduction of effective medical treatments for malignant melanoma patients, there is a tendency to introduce radiological assessments despite the lack of evidence.

The patients are randomized 1:1 to routine follow up for 3 years with regular doctors´ appointments according to national guidelines and the same follow up but with the addition of whole body CT or Positron Emission Tomography (PET) scans and blood tests. An interim analysis will be conducted when 1000 patients have been included.

Inclusion Criteria:

• At least 18 years of age.
• Radical surgery for Cutaneous Malignant Melanoma (CMM) stage IIb-c and III.
• Sufficient renal function for i.v. contrast scannings.

Exclusion Criteria:

• The patient is assessed as unfit to receive treatment in the case of recurrence.
• Life-expectancy less than 2 years due to concurrent disease (e.g., cardiac disease, terminal multiple sclerosis, liver cirrhosis).
• Inability to provide informed consent or refusal to do so.
• Inability to comply with the control or intense follow-up program.
• Participation in other clinical trials interfering with the control-program.
• Existing or previous malignancies within the past 5 years (except for in situ breast and cervical cancer, melanoma in situ and non-melanoma skin cancer).
• Pregnancy or currently planned pregnancy.