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| Name | Class |
|---|---|
| Tampere University of Technology | OTHER |
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Observational study of patients undergoing open heart surgery. During the procedure video clips of right heart are stored and compared to trans-oesophageal ultrasound recordings and ECG recordings.
Observational study of patients undergoing open heart surgery. During the procedure video clips of right heart are stored and compared to trans-oesophageal ultrasound recordings and ECG recordings. Right heart volume status and function is controlled and induced with theophylline and ventilator regulated positive end-expiratory pressure recordings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Experimental | Patients undergo procedure with stepwise measurements and ventilator + volume adjustment + iv theophylline Myocardial movement recording using videoscanning |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Theophylline | Drug | iv injection |
| |
| Ventilator positive end expiratory pressure adjustment |
| Measure | Description | Time Frame |
|---|---|---|
| Heart ventricle function | Changes in heart ventricle contraction status | Within the operation |
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| Measure | Description | Time Frame |
|---|---|---|
| ECG | Simultaneous ECG recording and analysis during outcome 4 measurements | Within the operation |
| Transesophageal ultrasound | Myocardial contraction range during video-clip |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jari Laurikka, MD,PhD | Professor, Cardio-thoracic Surgery | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tampere University Hospital, Heart Center | Tampere | 33521 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31847587 | Result | Soltani A, Lahti J, Jarvela K, Laurikka J, Kuokkala VT, Hokka M. Characterization of the anisotropic deformation of the right ventricle during open heart surgery. Comput Methods Biomech Biomed Engin. 2020 Feb;23(3):103-113. doi: 10.1080/10255842.2019.1703133. Epub 2019 Dec 17. | |
| 29717224 | Result | Soltani A, Lahti J, Jarvela K, Curtze S, Laurikka J, Hokka M, Kuokkala VT. An Optical Method for the In-Vivo Characterization of the Biomechanical Response of the Right Ventricle. Sci Rep. 2018 May 1;8(1):6831. doi: 10.1038/s41598-018-25223-z. |
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non-identifiable data to Tampere University of Technology research group
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| ID | Term |
|---|---|
| D013806 | Theophylline |
| ID | Term |
|---|---|
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
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Patients undergo medication intervention (w/intravenous theophylline) and ventilator volume adjustements, and serial ventricular function parameters are compared (pre-and post-intervention measurements).
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video analysts do not get information of the clinical data or procedure phase
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| Procedure |
Positive end-expiratory pressure variation |
|
| Videorecording | Device | Myocardial movement videorecording |
|
| Within the operation |
| Cardiac output | Measurement of cardiac output | Within the operation |
| D011687 |
| Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |