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The bispectral index (BIS) monitoring is an EEG-based method that uses electroencephalogram analysis and a complex algorithm to generate a numerical scoring 0-100 (0 flat line EEG, 100, wide awake) BIS monitoring allows noninvasive, objective measurement of level of consciousness of a sedated patient. A limited number of studies have used measurements of BIS monitoring to assist endoscopic sedation.There are studies using BIS monitoring to make sedation easy for ERCP procedures. However, the studies evaluating use of BIS for gastrointestinal endoscopy show inconsistent results.
The objective of this study is to evaluate effects of sedation on the dosage of propofol by monitoring with BIS values, hemodynamics, recovery parameters, respiratory functions and endoscopist satisfaction based on the hypothesis that the investigators would reduce the risk for respiratory depression using minimal doses of propofol in order to achieve the desired level of sedation with BIS monitoring.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| grup 1 | Ramsay Sedation Scale (RSS) Score monitoring |
| |
| Grup 2 | The bispectral index (BIS) monitoring |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The bispectral index (BIS) monitoring | Device |
| ||
| Ramsay Sedation Scale (RSS) Score monitoring |
| Measure | Description | Time Frame |
|---|---|---|
| Total dosage of propofol | initial dose 1 mg.kg-1 of propofol, maintenance dose: infusion of 4 mg/kg/h . In case of insufficient sedation, additional dose of 0.1 mg/kg propofol (IV) by monitoring with BIS values 65-75 during procedure | 1-3 hours |
| The heart rate (HR)(n/dk) | During procedure | 1-3 hours |
| mean systolic-diastolic blood pressure(mmHg) | during procedure | 1-3 hours |
| peripheral oxygen saturation (%) | During procedure | 1-3 hours |
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Inclusion Criteria:
Exclusion Criteria:
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patients in ASA 1-2 category scheduled for sedation and ERCP
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| ID | Term |
|---|---|
| D051383 | GRB10 Adaptor Protein |
| ID | Term |
|---|---|
| D048868 | Adaptor Proteins, Signal Transducing |
| D047908 | Intracellular Signaling Peptides and Proteins |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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| Behavioral |
|
| D002352 | Carrier Proteins |
| D011506 | Proteins |