Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:
This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Young Age - Healthy | These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. |
| |
| Old Age -Healthy | These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. |
| |
| Active Smoker | These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. |
| |
| Dermatological skin condition: Acne vulgaris | These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. |
| |
| Dermatological skin condition: Atopic dermatitis |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Skin Surface Lipid Collection and Skin Barrier Function | Other | All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices. |
| Measure | Description | Time Frame |
|---|---|---|
| Lipid Profile-aging | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day |
| Lipid Profile-acne | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day |
| Lipid Profile-atopic dermatitis | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day |
| Lipid Profile-smoking | The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin. | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Skin Barrier Function- aging | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day |
| Skin Barrier Function- acne |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Study patients will be recruited from the UC Davis Department of Dermatology, UC Davis undergraduate campus, Sacramento State University, and from the greater Sacramento area.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Raja K Sivamani, MD | UC Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UC Davis Department of Dermatology | Sacramento | California | 95816 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21967555 | Background | Ni Raghallaigh S, Bender K, Lacey N, Brennan L, Powell FC. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. Br J Dermatol. 2012 Feb;166(2):279-87. doi: 10.1111/j.1365-2133.2011.10662.x. | |
| 16086742 | Background | Sakai S, Kikuchi K, Satoh J, Tagami H, Inoue S. Functional properties of the stratum corneum in patients with diabetes mellitus: similarities to senile xerosis. Br J Dermatol. 2005 Aug;153(2):319-23. doi: 10.1111/j.1365-2133.2005.06756.x. |
| Label | URL |
|---|---|
| University of California-Davis Department of Dermatology Clinical Research | View source |
Not provided
Not provided
| ID | Term |
|---|---|
| D012907 | Smoking |
| D000152 | Acne Vulgaris |
| D003876 | Dermatitis, Atopic |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D017486 | Acneiform Eruptions |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
|
|
The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. |
| 1 day |
| Skin Barrier Function- atopic dermatitis | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day |
| Skin Barrier Function- smoking | The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration. | 1 day |
| D012625 |
| Sebaceous Gland Diseases |
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D017443 | Skin Diseases, Eczematous |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |