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| Name | Class |
|---|---|
| Radiological Society of North America | OTHER |
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To date, clinical tests are unable to differentiate between the cause of muscle stiffness, although a manual instrumented spasticity assessment for the lower limb that utilizes surface electromyogram has recently been proposed. This study intends to use shear wave elastography to assess individual muscle stiffness parameters and the individual response to botulinum toxin injection in the elbow and wrist flexors. Collection of baseline spasticity parameters could then be used to predict the effect of botulinum toxin type A and ultimately serve as a basis for development of a treatment model for muscle spasticity in patients with spastic cerebral palsy.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Botulinum toxin type A | Drug | Botox injection in upper extremity for spasticity in pediatric CP patients |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle Elasticity | Change in muscle elasticity (in kilopascal ) | From immediate pre-injection to 1 month post-injection. |
| Muscle Elasticity | Change in muscle elasticity (in m/s) | From immediate pre-injection to 1 month post-injection. |
| Measure | Description | Time Frame |
|---|---|---|
| Functional measures | Functional measures (MAS) | immediately pre- and immediately post-injection, and at 1 month, 3 months and 6 months post-injection. |
| Functional measures | Functional measures (PROM) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with unilateral spastic CP with presence of dynamic muscle spasticity in the elbow and/or wrist flexors, who will be able to provide consent. Consent may be obtained from a parent or legal guardian, as applicable.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital for Special Surgery | New York | New York | 10021 | United States |
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| ID | Term |
|---|---|
| D019274 | Botulinum Toxins, Type A |
| ID | Term |
|---|---|
| D001905 | Botulinum Toxins |
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
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| immediately pre- and immediately post-injection, and at 1 month, 3 months and 6 months post-injection. |
| D006867 |
| Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |
| D001426 | Bacterial Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D001427 | Bacterial Toxins |
| D014118 | Toxins, Biological |
| D001685 | Biological Factors |