The goal of the suggested research is to develop a treatment option using platelet rich plasma injection for regeneration of atropic nasal mucosa.

Specific aims of the suggested research is to (1) access the effect of platelet rich plasma in the patients with atropic rhinitis . Moreover, we will (2) compare the conservative treatments including saline nasal irrigation or saline nasal spray.

Clinical trials of platelet rich plasma injection for regeneration of atropic nasal mucosa.

• Injection interval and follow-up duration

  • Injection interval 2 weeks (upto total 3 consecutive injection)
  • Follow-up duration: 6 months

• Observation items, clinical assessment items and evaluation method

  • Access the nasal mucosal status using nasal speculum.
  • Access the nasal mucociliary function using saccharin test (primary outcome; once per month).
  • Fill in the nasal symptom scores using Nasal Obstruction Symptom Evaluation(NOSE) Instrument, Sino-Nasal outcome Test 20, and Visual analog scale (secondary outcome; once per month)

• The other atrophic rhinitis patients who did not want to perform platelet rich plasma injection

  • Random allocation to saline nasal irrigation or saline nasal spray group
  • Perform same observation items, clinical assessment items and evaluation method as well as platelet rich plasma injection group

Inclusion Criteria:

• Adults (>18 years)
• Complaint of atrophic rhinitis symptoms including nasal crusting, nasal burning sensation, and postnasal drip
• Atrophic rhinitis view on nasal endoscopic finding
• Patients who informed sufficient about other atrophic rhinitis treatment options including Young's operation, lubricants, or saline irrigation, but, want more other active treatment option.

Exclusion Criteria:

• Platelet related disorders
• Low serum platelet (<100,000/㎕)
• Other hematologic disorders
• Septicemia
• Take anticoagulant drugs