Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia

Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia

The study investigates whether Therapeutic Drug Monitoring (TDM) and continuous infusion (CI) of beta-lactam antibiotics optimises target concentrations in patients with bacteraemia.

Inclusion Criteria:

• Have a positive blood culture.
• Undergo treatment with either intravenous penicillin, ampicillin, piperacillin/tazobactam, dicloxacillin, cefuroxime or meropenem.
• Hospitalised at Hvidovre University Hospital.
• Age ≥ 18.
• Able to understand and give informed consent.
• Included in the study within 24 hours after the final positive blood culture answer.

Exclusion Criteria:

• Positive blood culture is interpreted as contamination.
• The patient dies before the intervention.