Sublobar Resection Versus Lobectomy for cT1N0M0 Non-small-cell Lung Cancer

A Multi-center, Randomized-controlled, Open-label Clinical Trial: Sublobar Resection Versus Lobectomy for cT1N0M0 Non-small-cell Lung Cancer

The incidence rate of ground-glass opacity (GGO) has been increasing these years. A great number of retrospective studies suggested that sublobar resection was better for some GGO patients. However, no prospective clinical study supports the perspective. This study is prospective, multi-center, randomized-controlled. The aim of this study is to investigate whether sublobar resection is inferior to lobectomy for cT1N0M0 non-small-cell lung cancer or not.

Inclusion Criteria:

• cT1N0M0 non-small-cell lung cancer
• ground-glass opacity, ≤2cm, GGO≥25%
• eligible for both lobectomy and sublobar resection
• intraoperative pathology is minimally-invasive adenocarcinoma or invasive adenocarcinoma
• intraoperative pathology of biopsied station 10 lymph node is negative

Exclusion Criteria:

• intraoperative pathology is benign nodule, atypical adenomatous hyperplasia, or adenocarcinoma in-situ
• intraoperative pathology of biopsied station 10 lymph node is positive
• multiple GGOs, lesions other than dominant lesion are malignant or >5mm
• history of thoracic surgery
• history of malignancy in recent 5 years
• unstable systemic disease
• patients with psychiatric disorders