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For patients with advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT), the survival benefit of transarterial chemoembolization (TACE) remains modest. This study aimed to investigate whether TACE in combination with irradiation stent placement (ISP) could prolong the survival in patients with HCC and PVTT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ISP-TACE group | During the study period, a total of 44 patients with HCC with PVTT underwent the irradiation stent placement and TACE were included in the ISP-TACE group. |
| |
| TACE group | During the study period, a total of 82 patients with HCC with PVTT underwent TACE monotherapy were included in the ISP-TACE group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ethiodized oil; doxorubicin;Gelfoam; | Drug | Conventional TACE was performed in both groups as follows. First, multiple angiographies were performed to detect the hepatic arterial anatomy and the possible feeding arteries of tumor, selective catheterization of the artery feeding the tumors was performed. A mixture of ethiodized oil was injected, followed by injection of Gelfoam particles. |
| Measure | Description | Time Frame |
|---|---|---|
| survival | The overall survival (OS) was defined as the time from first treatment to death or the patient's last follow up | 0-6 years |
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Inclusion Criteria:
Exclusion Criteria:
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Between January 2011 and December 2016, patients with HCC and PVTT underwent TACE combined with irradiation stent placement or TACE monotherapy as an initial treatment at the authors' center were retrospectively reviewed.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongda Hospital,Southeast University | Nanjing | Jiangsu | 210009 | China |
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| ID | Term |
|---|---|
| D004998 | Ethiodized Oil |
| D015607 | Stents |
| ID | Term |
|---|---|
| D007459 | Iodized Oil |
| D010938 | Plant Oils |
| D009821 | Oils |
| D008055 | Lipids |
| D028321 |
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| stent; idoine-125 | Device | In the ISP-TACE group, stent placement was performed one week before TACE. Under fluoroscopic and ultrasonic guidance, the outer stent was firstly placed at the site of the obstructed portal vein, and a self-expandable nitinol stent was immediately followed through a same 10-F sheath. |
|
| Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D019736 | Prostheses and Implants |
| D004864 | Equipment and Supplies |