This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy.

Cerebral palsy is one of the most common congenital (existing at or before birth) disorders of childhood.Spastic cerebral palsy causes stiffness and movement difficulties.There is no cure for the disease now.

This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy. hAEC will be intrathecal transplanted. Functional status is determined by Gross Motor Function Measure-66 and Fine Motor Function Measure. Spasticity is evaluated by using modified Ashworth scale(MAS).

Inclusion Criteria:

• Signed informed consent document;
• Gross Motor Function Classification System (GMFCS) levels III-V;
• Parents accepted voluntarily cell therapy for their children and followed-up.

Exclusion Criteria:

• Have a history of severe allergic;
• Serological tests such as AIDS, hepatitis B, syphilis, etc;
• Hereditary metabolic diseases of nervous system;
• Tumor or Hematological diseases.