The aim of the study is to evaluate the use of irreversible electroporation in the treatment of locally advanced cancers of the head of pancreas with vascular spread. This technique would allow to treat the unresectable part of the tumor to make it more accessible for a secondary surgery.

Inclusion Criteria:

• Patients with histologically proven adenocarcinoma of the head of the pancreas (fine needle aspiration or biopsy)
• Pancreatic adenocarcinoma locally advanced on imaging at diagnosis
• Tumor of less than 7 cm in largest diameter
• No chemotherapy or abdominal radiotherapy within five years before the inclusion in the study

Exclusion Criteria:

• Pancreatic adenocarcinoma of more than 7 cm of diameter or immediately operable on imaging data
• Patient with contraindication of NanoKnife use
• Patient with neurostimulator
• Epileptic patient or with a myocardial infarction lasting less than 2 months
• Presence of visceral or lymph node metastases or peritoneal carcinosis at the initial workup
• Patient who cannot be treated with muscle blockers (curare)
• Patient with a metallic stent or a medical device implanted near the area treated by electroporation