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| Name | Class |
|---|---|
| Validia Rehabilitation Center | UNKNOWN |
| University of Helsinki | OTHER |
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The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Long-term PAS | Experimental | The intervention is given to one hand only |
|
| No intervention | No Intervention | Contralateral hand of the same patient |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| long-term paired associative stimulation | Device | Paired associative stimulation (PAS) administered several times per week for 6 weeks to one hand. PAS comprises transcranial magnetic stimulation (eXimia magnetic stimulator, Nexstim Ltd, Helsinki, Finland) and peripheral nerve stimulation (given with Dantec Keypoint® electroneuromyography device (Natus Medical Incorporated, Pleasanton, CA, USA)). |
| Measure | Description | Time Frame |
|---|---|---|
| Daniels and Worthingham's Muscle Testing | each hand muscle is evaluated on 0-5 scale | 2 days after the last stimulation session |
| Daniels and Worthingham's Muscle Testing | each hand muscle is evaluated on 0-5 scale | 1 month after the last stimulation session |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BioMag laboratory | Helsinki | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31886442 | Result | Tolmacheva A, Savolainen S, Kirveskari E, Brandstack N, Makela JP, Shulga A. Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series. Clin Neurophysiol Pract. 2019 Aug 13;4:178-183. doi: 10.1016/j.cnp.2019.07.002. eCollection 2019. |
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| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
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