Study Evaluating the Effect of Multiple Doses of Itraconazole on the Drug Lu AF35700 in Healthy Young Men and Women

Interventional, Open-label, One-sequence Crossover Study Evaluating the Effect of Multiple Doses of Itraconazole (Inhibitor of CYP3A4/5) on the Pharmacokinetics, Safety and Tolerability of Lu AF35700 in Healthy Young Men and Women

This study will investigate the effect of multiple doses of the strong P450 enzyme inhibitor itraconazole on the pharmacokinetics of Lu AF35700 in healthy subjects.

Inclusion Criteria:

• Men, aged ≥18 and ≤55 years. body weight ≥50 kg
• women, aged ≥18 and ≤45 years, body weight ≥50 kg
• Good general health as assessed using detailed medical history, laboratory tests, and physical examination
• Known CYP2D6 and CYP2C19 genotype

Exclusion Criteria:

• Pregnant or lactating
• Subject has previously been dosed with Lu AF35700

Other protocol defined inclusion and exclusion criteria may apply