This study will determine if a structured walking intervention will help maintain or improve physical activity levels, physical function and quality of life in hematopoietic stem cell transplant patients.

The researchers will quantify the decline in physical function of HSCT patients using valid and reliable tests aimed to mimic activities of daily living, quantify cardiovascular health, and quantify muscle power declines. Also, patients will undergo a walking program during their hospitalization, which is designed to increase physical activity levels and maintain and improve physical function and quality of life. Additionally, using valid and reliable questionnaires, the researchers will gauge perception of exercise, quantify current exercise levels, determine preference of exercise programs and counseling, and measure differences in quality of life before and after HSCT treatment.

Inclusion Criteria:

• Be between 40 and 80 years of age
• Willing and able to provide written informed consent in English
• Ability to comprehend the purpose of the study
• Be scheduled to receive an autologous or allogeneic hematopoietic stem cell transplant at Sylvester Comprehensive Cancer Center
• Have an expected hospital stay of at least 2 weeks
• Not currently be participating in an exercise training program

Exclusion Criteria:

• Dementia, altered mental status, or psychiatric condition
• Received erythropoiesis-stimulating proteins within 4 weeks prior to enrollment
• Comorbid conditions that would contraindicate exercise testing
• Undergoing concurrent non-transplant-related chemotherapy or radiation