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Prospective Italian study aimed to provide a description of the population affected by Epithelioid Sarcoma (ES)
The present prospective national study aims to provide a description of the population affected by ES, an insight into the natural history of the disease and an answer some on the outstanding questions on its management. Also, it will focus on enhancing any differences between the two ES variants (classical-type and proximal-type) in order gain a better understanding of the disease, tailor the treatment and lastly improve outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Epitheloid Sarcoma patients | Patients with diagnosis of localized or advanced epitheloid sarcoma seen in the Italian reference centers for sarcoma treatment that receive treatment for Epitheloid Sarcoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Treatment for Epitheloid Sarcoma | Other | Treatment Epitheloid Sarcoma according the disease guideline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Type of treatment given to patients with ES | Number of chemotherapy treatment received patients affected by ES | From diagnosis until the date of death from any cause assessed up to 60 months |
| Measure | Description | Time Frame |
|---|---|---|
| Radiotherapy treatments | Number of patients affected by localized ES who received radiotherapy | From the time of diagnosis and then every 6 months up to 60 months |
| Chemotherapy treatments | Number of patients affected by localized ES who received chemotherapy |
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Inclusion criteria
Exclusion criteria
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Patient affected by epithelioid sarcoma according to 2014 WHO classification
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Annamaria Frezza, MD | Contact | 003902390 | 2803 | annamaria.frezza@istitutotumori.mi.it |
| Name | Affiliation | Role |
|---|---|---|
| Paolo Casali, MD | Fondazione IRCCS INT Milano | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori - IRST | Recruiting | Meldola | FC | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26645461 | Background | Thway K, Jones RL, Noujaim J, Fisher C. Epithelioid Sarcoma: Diagnostic Features and Genetics. Adv Anat Pathol. 2016 Jan;23(1):41-9. doi: 10.1097/PAP.0000000000000102. | |
| 9042279 | Background | Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD. "Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol. 1997 Feb;21(2):130-46. doi: 10.1097/00000478-199702000-00002. |
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| ID | Term |
|---|---|
| D012509 | Sarcoma |
| ID | Term |
|---|---|
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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Tumor sample materiale
| From the time of diagnosis and then every 6 months up to 60 months |
| Predictive biomarkers for response | Tumor biomarkers expression in tumor tissue of patients affected by ES | At time of diagnosis and at the time of any progression where a biopsy is performed up to 60 months |
| Istituto Europeo di Oncologia | Recruiting | Milan | MI | 20141 | Italy |
|
| Istituto Clinico Humanitas | Recruiting | Rozzano | MI | 20089 | Italy |
|
| Azienda Ospedaliera Universitaria Paolo Giaccone | Recruiting | Palermo | PA | 90127 | Italy |
|
| Fondazione del Piemonte per l'Oncologia IRCC Candiolo | Recruiting | Candiolo | Torino | 10060 | Italy |
|
| Istituto Ortopedico Rizzoli - Unit of Chemotherapy of Muscoloskeletal Tumors | Recruiting | Bologna | 40136 | Italy |
|
| Fondazione IRCCS INT Milano | Recruiting | Milan | Italy |
|
| Irccs Istituto Oncologico Veneto (Iov) | Recruiting | Padova | Italy |
|
| Ospedale Misericordia e Dolce Ist. Toscano Tumori, Az. USL4 | Recruiting | Prato | 59100 | Italy |
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| Campus Biomedico | Recruiting | Roma | Italy |
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| Istituti Fisioterapici Ospitalieri di Roma | Recruiting | Roma | Italy |
|
| 4014539 | Background | Chase DR, Enzinger FM. Epithelioid sarcoma. Diagnosis, prognostic indicators, and treatment. Am J Surg Pathol. 1985 Apr;9(4):241-63. |
| 3392084 | Background | Bos GD, Pritchard DJ, Reiman HM, Dobyns JH, Ilstrup DM, Landon GC. Epithelioid sarcoma. An analysis of fifty-one cases. J Bone Joint Surg Am. 1988 Jul;70(6):862-70. |
| 8656704 | Background | Halling AC, Wollan PC, Pritchard DJ, Vlasak R, Nascimento AG. Epithelioid sarcoma: a clinicopathologic review of 55 cases. Mayo Clin Proc. 1996 Jul;71(7):636-42. doi: 10.1016/S0025-6196(11)63000-0. |