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| ID | Type | Description | Link |
|---|---|---|---|
| N° IDRCB 2017-A00306-47 | Other Identifier | French Government |
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Little is known about bronchoalveolar lavages performed for cytological assessment during bronchial fibroscopy in critically ill patients. Frequency of use, indications, actual contribution to diagnosis and therapeutic decision, and complications have not been extensively assessed.
The primary objective of this multi center, prospective, observational study is to describe the frequency of use of bronchoalveolar lavages for cytological assessement in critically ill patients, identify their indications, assess their contribution to diagnosis and therapeutic decisions, and estimate the frequency of induced respiratory events.
Secondary objectives will be to
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bronchoalveolar lavage | Procedure | bronchoalveolar lavages performed for cytological assessment in critically ill patients with lung diseases, intubated or not |
| Measure | Description | Time Frame |
|---|---|---|
| quality of performed bronchoalveolar lavage | pathologists examining bronchoalveolar lavage specimen will classify bronchoalveolar lavage as "of poor quality" or of "good quality" based upon cytologic assessment: bronchial cell count (not more than 5%) and alveolar cell count (above 50,000/mL). | 72 hours |
| contribution to diagnosis and/or therapeutic decision | Investigators will be ask to answer the following question: Did the bronchoalveolar lavage results contribute to diagnosis and/or therapeutic decision: Yes or No | 72 hours |
| frequency of use | the frequency of use of bronchoalveolar lavage will be describe and expressed as the proportion of patients who underwent bronchoalveoalr lavage upon the total number of patients admitted in the recruiting intensive care units during the study period | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of respiratory rate | respiratory rate will be assessed before the bronchoalveolar lavage and 8 times during the 24 hours following the bronchoalveolar lavage | 24 hours |
| Evolution of oxygen needs |
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Inclusion Criteria:
Exclusion Criteria:
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adult patients hospitalized in intensive care unit with acute and/or chronic lung disease that need bronchoalveolar lavage as part of the diagnostic work up
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| Name | Affiliation | Role |
|---|---|---|
| Toufik KAMEL, MD | CHR Orléans | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU d'ANGERS | Angers | France | ||||
| CH d'ANGOULEME |
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Oxygen needs, in L/min in patients under conventional nasal or facial oxygen therapy, or expressed in FiO2 in patients under nasal high flow oxygen or under invasive or noninvasive ventilation, will be recorded before bronchoalveolar lavage and 8 times during the following 24 hours.
| 24 hours |
| Need of tracheal intubation | Percentage of patients not intubated while undergoing bronchoalveolar lavage that will need intubation within 24 hours | 24 hours |
| Angoulême |
| France |
| CH Victor DUPOUY | Argenteuil | France |
| CHU de DIJON | Dijon | France |
| Hôpital RAYMOND POINCARE | Garches | France |
| CHD de VENDEE | La Roche-sur-Yon | 85925 | France |
| CH de LA ROCHELLE | La Rochelle | 17019 | France |
| Hopital de La Timone | Marseille | France |
| Hôpital Nord de Marseille | Marseille | France |
| CH de MONTAUBAN | Montauban | France |
| CHRU de NANTES | Nantes | 44093 | France |
| CHR d'ORLEANS | Orléans | France |
| CHRU de POITIERS | Poitiers | 86021 | France |
| CHU de STRASBOURG | Strasbourg | 67000 | France |
| CHU de STRASBOURG NHC | Strasbourg | France |
| CHRU de TOURS | Tours | 37044 | France |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D018893 | Bronchoalveolar Lavage |
| ID | Term |
|---|---|
| D007507 | Therapeutic Irrigation |
| D008919 | Investigative Techniques |
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