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| Name | Class |
|---|---|
| University Grenoble Alps | OTHER |
| Centre Hospitalier Universitaire Vaudois | OTHER |
| Emergency Department, Hospital of Valais, Sion | UNKNOWN |
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Serum Potassium Rate (PR) is a key indicator for medical management of patients with accidental hypothermia particularly for hypothermia related cardiac arrest (CA).
Experts recommend a cut-off value for PR of 12 mmol/l for all hypothermic victims and 8 mmol/l for avalanche casualties. Any patient presenting a PR lower than the cut-off value should be considered for Extracorporeal Rewarming. This therapeutic strategy is vital for patient survival.
However, there is no consensus about what type of vessels should be punctured in order to obtain an accurate potassium rate and what type of measurement technics should be used to measure this potassium rate.
The investigators hypothesize that potassium rate in these patients will differ by 1 mmol/l in blood samples collected from a peripheral vein in contrast to a central vein.
The investigators study is a prospective observational, multicentre study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypothermia related cardiac arrest | Other | blood draw from three different vessels punctured in the emergency room (central vein, peripheral vein, artery) and comparison of potassium rate and other biological values between the different sites of blood draw and two different measuring techniques (laboratory vs. blood gas analyser) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood draw from three different vessels | Diagnostic Test | Patient in cardiac-arrest and cold exposure, diagnostic test: blood draw from three different vessels (central vein, artery, peripheral vein) and measuring of PR |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of potassium rate in central venous blood and blood from a peripheral vein (measured in mmol/l) | Comparison of PR in central venous blood and blood from a peripheral vein (measured in mmol/l) | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of potassium rate in venous and arterial blood (measured in mmol/l) | Comparison of potassium rate in venous and arterial blood (measured in mmol/l) | 24 hours |
| Comparison of potassium rate from laboratory analysis and at bedside via blood gas analyser (measured in mmol/l) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marc Blancher, MD | Contact | +33 (0) 476634266 | MBlancher@chu-grenoble.fr | |
| Sarah K Buse | Contact | +49 (0) 15201911437 | sarah@drbuse.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Vaudois | Recruiting | Lausanne | Valais | 1011 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31842931 | Derived | Pasquier M, Blancher M, Buse S, Boussat B, Debaty G, Kirsch M, de Riedmatten M, Schoettker P, Annecke T, Bouzat P. Intra-patient potassium variability after hypothermic cardiac arrest: a multicentre, prospective study. Scand J Trauma Resusc Emerg Med. 2019 Dec 16;27(1):113. doi: 10.1186/s13049-019-0694-3. |
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| ID | Term |
|---|---|
| D007035 | Hypothermia |
| D006947 | Hyperkalemia |
| D006323 | Heart Arrest |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014883 | Water-Electrolyte Imbalance |
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Comparison of potassium rate from laboratory analysis and at bedside via blood gas analyser (measured in mmol/l) |
| 24 hours |
| Comparison of the time difference between laboratory analysis and blood gas analyzer at bed side (measured in minutes) | Comparison of the time difference between laboratory analysis and blood gas analyzer at bed side (measured in minutes) | 24 hours |
| Survival and neurological outcome as measured by the Cerebral Performance Category Scale | Survival and neurological outcome as measured by the Cerebral Performance Category Scale | 3 months |
| Study of biological parameters to calculate the Strong Ion Gap (measured in mEq/l) according to the Stewart Approach |
SIDe = 1000 × 2.46 × 10-11 × PaCO2/(10-pH) + [A-] To quantify unmeasured charges, the SIG will be calculated as: SIG = SIDa - SIDe | 24 hours |
| Hospital of Valais | Recruiting | Sion | Valais | 1951 | Switzerland |
|
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |