Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery

Cardiac and Endothelial Function Response to Early Exercise Training (CEFREET Study) After Coronary Artery Bypass Surgery: a Randomized Clinical Trial

Background: Coronary artery bypass grafting (CABG) due to coronary artery disease (CAD) is one of the main surgical procedures performed in the area of cardiology. Individuals undergoing CABG present sarcopenia, decreased muscle strength of the lower limbs, decreased respiratory muscle strength and dyspnea due to immobility in the bed and the inherent conditions of the disease itself. Cardiorespiratory rehabilitation techniques are rarely used with measurement in hospitals and can greatly favor an early and effective reestablishment to this population in several parameters. Objective: To evaluate the effect of functional electrical stimulation (FES), ventilatory muscle training (TREMVEN), early aerobic training (AERO) and isometric handgrip training (ISO) on the functional capacity, endothelial function and cardiac parameters of individuals undergoing CABG. Methods: In a randomized clinical trial, volunteers will be allocated into four groups: EEF, TREMVEN, AERO or ISO in the preoperative period of CABG. After 48 hours (postoperative midway) of the surgery, the protocol will begin until after hospital discharge. The endpoints evaluated will be: functional capacity, respiratory muscle strength, systolic and diastolic function, arterial endothelial function, inflammatory profile and plasma levels of vascular endothelial growth factor (VEGF). Scientific contributions: Phase 1 cardiorespiratory rehabilitation with alternative interventions may provide an increase in functional capacity, strengthening of respiratory muscles, improvement in cardiac and endothelial functions, as well as increased systemic VEGF levels (myocardial revascularization) and improvement of the inflammatory profile, effectively forwarding the individuals to the rehabilitation phase 2.

Inclusion Criteria:

• Be elective for the first CABG due to a previous ischemic event;
• Do not present other associated heart diseases;
• Absence of history of neuromuscular, autoimmune and infectious diseases;
• Age between 50 to 75 years;
• Signature of the Informed Consent Term.
• No hyperreactivity during the pre-intervention evaluation tests;
• No chronic renal failure; history of malignant disease with life expectancy <2 years;
• No severe arrhythmias, angina pectoris, pulmonary embolism and thrombophlebitis;
• Do not have orthopedic limitations or any physical or mental limitation that prevents the proposed exercises from being performed;
• Present Left Ventricular Ejection Fraction (LVEF) > 40% in 48h after CABG, and
• After the physical training period, individuals who have not completed a minimum of 80% of the protocol will be excluded from the sample due to refusal or withdrawal.