Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease

Determinants of Volumetric Bone Mineral Density at the Tibia and Radius and it's Relationship With Osteoporotic Fractures in Idiopathic Parkinson's Disease

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

Inclusion Criteria:

• Patients with idiopathic Parkinson's disease according to the criteria of the UKPDBB.
• Parkinson's disease of moderate severity (Index HOEHN and Yahr <5)
• Patient can respond to questionnaires, with or without help

Exclusion Criteria:

• Patients with active psychiatric illness preventing the realization of examinations
• Severe Parkinson's disease (Index HOEHN and Yahr ≥5 )
• Heavy-morbidity including heart failure NYHA> 3 or chronic respiratory failure, terminal or severe renal impairment known dialyzed
• Pregnancy