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| Name | Class |
|---|---|
| AFRICSanté | OTHER |
| Institute of Tropical Medicine, Belgium | OTHER |
| Institut de Recherche en Sciences de la Sante, Burkina Faso | OTHER_GOV |
| University of Ouagadougou, Burkina Faso |
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This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in three Provinces of Burkina Faso. The study design included an 18-months baseline study to measure baseline cumulative incidence of cysticercosis followed by an 18-month post randomization study to measure the effectiveness of the intervention. Sixty villages of three Provinces of Burkina Faso were included. The primary outcome was the change in the baseline to post randomization cumulative incidence in the intervention group compared to the control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Educational package | Active Comparator | The educational package included the offering of the Self-Esteem , Associative strengths, Resourcefulness, Action-planning and Responsibility (SARAR) Participatory Hygiene and Sanitation Transformation (PHAST) approach, a 52 minutes educational movie and accompanying cartoon booklet. The package was developed using the PRECEDE approach. |
|
| Control | No Intervention | The control group did not receive any intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Educational package | Other | The educational package was offered to 30 villages post randomization. The field team completed the SARAR PHAST with community members for 2-3 days in each intervention village. The movie was projected every night for 2-3 days in each intervention village. |
| Measure | Description | Time Frame |
|---|---|---|
| Human active cysticercosis cumulative incidence | Sero conversion to the AgELISA test to detect antigens of cysticercosis | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization |
| Measure | Description | Time Frame |
|---|---|---|
| Porcine active cysticercosis prevalence | Sero-positivity to the AgELISA test to detect antigens of cysticercosis | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization |
| Change in knowledge, attitude and practices |
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The unit of randomization and analysis of this study is the village. Therefore, the eligibility criteria were determined at the village level.
Inclusion Criteria:
Exclusion Criteria:
At the individual level, the following eligibility criteria were used:
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hélène Carabin, DVM PhD | University of Oklahoma | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AFRICSanté | Bobo-Dioulasso | Burkina Faso |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25544938 | Background | Carabin H, Traore AA. Taenia solium taeniasis and cysticercosis control and elimination through community-based interventions. Curr Trop Med Rep. 2014 Dec 1;1(4):181-193. doi: 10.1007/s40475-014-0029-4. | |
| 22289127 | Background | Nitiema P, Carabin H, Hounton S, Praet N, Cowan LD, Ganaba R, Kompaore C, Tarnagda Z, Dorny P, Millogo A, Efecab. Prevalence case-control study of epilepsy in three Burkina Faso villages. Acta Neurol Scand. 2012 Oct;126(4):270-8. doi: 10.1111/j.1600-0404.2011.01639.x. Epub 2012 Jan 31. |
| Label | URL |
|---|---|
| Website of the facility in Burkina Faso which managed the study | View source |
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De-identified data will be made available at the time of publication as per NIH requirements
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Oct 12, 2014 | Feb 12, 2018 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D003551 | Cysticercosis |
| ID | Term |
|---|---|
| D013622 | Taeniasis |
| D002590 | Cestode Infections |
| D006373 | Helminthiasis |
| D010272 | Parasitic Diseases |
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| OTHER |
| University Hospital, Limoges | OTHER |
| Centre Universitaire Souro Sanou | UNKNOWN |
| Technical University of Munich | OTHER |
| Brown University | OTHER |
This is a pre-post community-based randomized controlled trial. The unit of randomization is the village (community)
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|
Change in answers to the questionnaire through time
| baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization |
| Cumulative incidence of epilepsy and progressively worsening severe chronic headaches | development of neurological disorders among those followed up at least twice | baseline, 18 months follow-up pre randomization, 18 months follow-up post randomization |
| Stigmatization of epilepsy | Attitudes and knowledge regarding epilepsy post randomization | 18 months follow-up post randomization |
| 26580325 | Background | John CC, Carabin H, Montano SM, Bangirana P, Zunt JR, Peterson PK. Global research priorities for infections that affect the nervous system. Nature. 2015 Nov 19;527(7578):S178-86. doi: 10.1038/nature16033. |
| 26588468 | Background | Carabin H, Millogo A, Cisse A, Gabriel S, Sahlu I, Dorny P, Bauer C, Tarnagda Z, Cowan LD, Ganaba R. Prevalence of and Factors Associated with Human Cysticercosis in 60 Villages in Three Provinces of Burkina Faso. PLoS Negl Trop Dis. 2015 Nov 20;9(11):e0004248. doi: 10.1371/journal.pntd.0004248. eCollection 2015 Nov. |
| 27884445 | Background | Dermauw V, Ganaba R, Cisse A, Ouedraogo B, Millogo A, Tarnagda Z, Van Hul A, Gabriel S, Carabin H, Dorny P. Taenia hydatigena in pigs in Burkina Faso: A cross-sectional abattoir study. Vet Parasitol. 2016 Oct 30;230:9-13. doi: 10.1016/j.vetpar.2016.10.022. Epub 2016 Oct 24. |
| 28426664 | Background | Carabin H, Winkler AS, Dorny P. Taenia solium cysticercosis and taeniosis: Achievements from the past 10 years and the way forward. PLoS Negl Trop Dis. 2017 Apr 20;11(4):e0005478. doi: 10.1371/journal.pntd.0005478. eCollection 2017 Apr. No abstract available. |
| 28569208 | Result | Ngowi H, Ozbolt I, Millogo A, Dermauw V, Some T, Spicer P, Jervis LL, Ganaba R, Gabriel S, Dorny P, Carabin H. Development of a health education intervention strategy using an implementation research method to control taeniasis and cysticercosis in Burkina Faso. Infect Dis Poverty. 2017 Jun 1;6(1):95. doi: 10.1186/s40249-017-0308-0. |
| 30653519 | Derived | Sahlu I, Bauer C, Ganaba R, Preux PM, Cowan LD, Dorny P, Millogo A, Carabin H. The impact of imperfect screening tools on measuring the prevalence of epilepsy and headaches in Burkina Faso. PLoS Negl Trop Dis. 2019 Jan 17;13(1):e0007109. doi: 10.1371/journal.pntd.0007109. eCollection 2019 Jan. |
| D007239 |
| Infections |